Cowboys ★ Indians is a tragic love story set in the modern west. It follows the life of Angel, a beautiful but damaged Paiute Indian woman who was lead to live desperately on the edge after having been raped. Earning a living in a topless bar called the Round-Up, Angel tries her best to raise her son, Gas, the ill-begotten son of the tragic rape. When Gas is fourteen he runs away from home and is picked up by a hard-up cowboy, Twisty, who was present on the fateful night 14 years ago. Twisty relates the tragic romance he had with his mother, elucidating many unanswered questions for the boy. The cowboy and the boy form a bond that leads them back to Angel where once re-united, and with the truth brought to light, a possible way forward is revealed.